Real-World Data vs Controlled Lab Data: Bridging the Gap in Sleep Research
Two paradigms have shaped the way sleep is studied. The first prizes precision under controlled conditions and produces the high-resolution polysomnography traces that remain the diagnostic standard for sleep architecture. The second prizes ecological validity and produces the multi-week behavioral recordings that capture how participants actually sleep at home. Both paradigms answer real questions, and both fall short when used in isolation. Modern protocols increasingly draw from both, with research-grade multi-week recording platforms such as ActTrust 2 filling the role that home-based instrumentation needs to play. The Strengths and Limits of Polysomnography Polysomnography records EEG, EOG, EMG, respiratory effort, and oxygenation, which is the only way to stage REM and NREM sleep with current technology. That precision comes at a cost. Lab nights are unfamiliar, expensive, and unrepresentative of typical home sleep. The first-night effect alone introduces measurable distorti...